Manzano is taking the Chargers so seriously, he ranked Jim Harbaugh's club at No. 2 overall behind only the defending Super Bowl champion Philadelphia Eagles. The Tampa Bay Buccaneers, San Francisco 49ers and Indianapolis Colts followed No. 3 Buffalo in that order.

On paper, the Bills’ matchup with the Saints is a huge mismatch. New Orleans has holes all over their roster, which the Seahawks exposed frequently in Week 3. Considering how Buffalo is widely believed to be a better team than them, that means this game could get ugly if they come out and play their brand of football from the get-go.

ORHARD PARK, N.Y. – The Buffalo Bills stay at home in week 4 against a winless New Orleans Saints squad. The Bills got an extended break, last playing on Thursday Night Football in week 3 against the Miami Dolphins. Buffalo won that game, 31-21, improving to 3-0 on the season. Now they look for their first 4-0 start since 2020.

About receiving prospects Keon Coleman, Khalil Shakir, Elijah Moore and Josh Palmer. And even about Stefon Diggs.MORE: Josh Allen and Bills have whopping advantage over Saints in talent & travelWhile the former four-time Pro Bowl star struggles with his second team in two seasons - first the Houston Texans,

The Buffalo Bills head into Week 4 of NFL action undefeated, now set to face a rather downtrodden team in the New Orleans Saints. The last things the Bills should do is treat an opponent they rare see as an afterthought,

To celebrate the Bills Rivalries game, Wegmans will be selling limited edition Bills items in their stores.In August, the team revealed their “cold front” uniforms for their game against the Patriots on Sunday,

Dorian Williams will start again for Milano, and with the Bills utilizing more three-linebacker sets this year, that means veteran Shaq Thompson - who has battled a hamstring injury since training camp - will get extra reps. Last week against Miami he played 21 snaps.

The Bills have been managing just four injuries this week, and all four, as predicted, will enter the weekend with a designation for Sunday. Along with Oliver and Milano being ruled out, right tackle Spencer Brown and defensive end A.J. Epenesa will be listed as questionable.