Development of novel influenza neuraminidase inhibitors is critical for preparedness against influenza outbreaks. Knowledge of the neuraminidase enzymatic mechanism and transition-state analogue ...

In this work, we exemplify the scope and limitations of functional NA inhibition assays by showing the inhibitory activity of three well-known NAIs (oseltamivir, zanamivir and DANA), two novel ...

Either zanamivir or oseltamivir may be used for treatment of infection with influenza A or influenza B. Current policy issues will inform recommendations for the future use of neuraminidase ...

Oseltamivir carboxylate (GS4071) and zanamivir (GG167) were obtained from GlaxoSmithKline (Uxbridge, UK) and F. Hoffmann-La Roche AG (Basel, Switzerland), respectively. N-Acetyl-2,3-dehydro-2 ...