Is our understanding of the pathogenesis of Wilson's disease increased? We have found that a concentration of hepatic copper greater than 250 μg per gram dry weight is virtually necessary and ...

Abdominal Form of Wilson's Disease as a Clinical Entity All 5 of ... above will be necessary to confirm this uniform theory of pathogenesis. Five cases of cirrhosis of the liver associated with ...

Wilson disease. In: Schiff's Diseases of the Liver ... copper excretion (chelating agents D-penicillamine and trientine). Pathogenesis of copper toxicity. The main pathways of copper overload ...

Osteoporosis is a common complication of chronic liver disease. Although bone demineralization has been noted in Wilson's disease—which involves pathologic copper accumulation—the exact ...

Adapted from Schilsky ML, Tavil AS. Wilson disease. In: Schiff's Diseases of the Liver. Philadelphia: Lippincott Williams and Wilkins; 2006:1023–1040. Most practitioners prefer start with trientine.