To mature them and induce meiosis, Kono's team had to transfer them into an enucleated oocyte from a wild-type mouse. With the haploid genome of the mutant oocyte in hand, they were finally ready ...
The PS1 knock-in line was generated by introducing two point mutations in the wild-type mouse PSEN1, corresponding to the mutations M233T and L235P. APP751SL overexpresses human APP751 carrying the ...
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