Early in the beginning of the COVID-19 pandemic, scientists predicted the coronavirus would mutate slowly. They were wrong. Hundreds of thousands of viral mutations and multiple seasonal waves later, ...

SARS-CoV-2 is a highly pathogenic virus that evades antiviral immunity by interfering with host protein synthesis, mRNA stability, and protein trafficking. The SARS-CoV-2 nonstructural protein 1 (Nsp1 ...

New research has uncovered a series of mutations in the SARS-CoV-2 spike protein that enhanced the virus' ability to infect the brains of mice. The findings may help scientists understand its ...

Since the start of the COVID-19 pandemic, there has been controversy surrounding the origins of SARS-CoV-2. New research from the University of California, San Diego (UCSD), School of Medicine ...

UCSF researchers designed new drug candidates that potently block MPro, a viral enzyme that's crucial for SARS-CoV-2 replication. One of these drug candidates, AVI-4516, is shown (center) bound to the ...

A landmark study shows that bat viruses closely related to SARS-CoV-1 and SARS-CoV-2 emerged far from outbreak sites, pointing to the wildlife trade, not natural bat movement, as the most plausible ...

SARS-CoV-2, the virus responsible for COVID-19, infects cells by binding its spike protein to angiotensin-converting enzyme 2 (ACE2) receptors. Blocking this interaction with inhibitors could prevent ...

After an in-depth analysis of the genetic material from hundreds of swabs taken from the walls, floors, machines and drains inside the Huanan Seafood Wholesale Market in Wuhan, China — a site that’s ...