Wayne Knight — who played Seinfeld’s portly postman nemesis Newman on the hit ’90s series — dropped more than 100 pounds after a doctor warned he was eating himself to death! Knight, 69 ...

Wayne Knight is pictured during a “Seinfeld” fan event at the Donald E. Stephens Convention Center in Rosemont, Illinois, on August 18, 2024. (Barry Brecheisen/WireImage) ...

Wayne Knight is pictured during a “Seinfeld” fan event at the Donald E. Stephens Convention Center in Rosemont, Ill., on Aug. 18, 2024. (Credit: Barry Brecheisen/WireImage) ...

Wayne Knight, who appeared in 44 episodes of “Seinfeld” as Jerry’s neighbor and nemesis, was the subject of plenty of weight jokes during the series’ run in the 1990s.