Source Reference: Pereira T, et al "Viscosupplementation for knee osteoarthritis: systematic review and meta-analysis" BMJ 2022; DOI: 10.1136/bmj-2022-069722. Share on Facebook. Opens in a new tab ...

The FDA approved viscosupplementation for osteoarthritis of the knee in 1997. There are several products on the market, one of which is a natural product made from the comb of a rooster.

Compared with placebo, viscosupplementation provided a small reduction in pain but increased risk of serious adverse events in patients with knee osteoarthritis, according to published results ...