In the absence of depolymerizers, GDP-bound tubulin shows distinctive intra-dimer and inter-dimer interactions and thus distinguishes the GTP and GDP interfaces. A cold-stable tubulin polymer with ...

tubulin, that measure around 25 nm in diameter. The α- and β tubulins are encoded by small families of related genes and combine to form a dimer that the microtubules are constructed from.

Microtubules are cell constituents that display several astounding properties and a unique pattern of behavior during the cell cycle. Microtubules are regulated by several proteins and complexes ...

[17] This pattern of effects on microtubule stabilization is distinct from that of other clinically important tubulin-targeting agents, which include taxanes, epothilones, and vinca alkaloids.