In the absence of depolymerizers, GDP-bound tubulin shows distinctive intra-dimer and inter-dimer interactions and thus distinguishes the GTP and GDP interfaces. A cold-stable tubulin polymer with ...

tubulin, that measure around 25 nm in diameter. The α- and β tubulins are encoded by small families of related genes and combine to form a dimer that the microtubules are constructed from.

[17] This pattern of effects on microtubule stabilization is distinct from that of other clinically important tubulin-targeting agents, which include taxanes, epothilones, and vinca alkaloids.

Microtubules are cell constituents that display several astounding properties and a unique pattern of behavior during the cell cycle. Microtubules are regulated by several proteins and complexes ...

Several diagnostic strategies using ultrasound imaging, measurement of D-dimer, and assessment of clinical probability of disease have proved safe in patients with suspected deep-vein thrombosis ...

Then, patients were randomized to either D-dimer testing or no D-dimer testing (controls). In the D-dimer group, patients with low clinical probabilities and negative D-dimer tests underwent no ...

Nickel-cobalt metal dimer on nitrogen-doped carbon can catalyze electrolysis under both acidic and basic conditions. The limited reservoir of fossils fuels and the ever-increasing threats of ...

For patients without and with PE, the median D-dimer values were 1.0 and 6.1 µg/mL, respectively; D-dimer values ranged from 0.2 to 128 µg/mL and from 0.5 to more than 10,000 µg/mL, respectively.

of the ZF2001 vaccine (with each dose containing 25 μg of RBD-dimer protein with 0.25 mg of aluminum hydroxide in 0.5 ml of buffer) or placebo (with each dose containing 0.25 mg of aluminum ...