The M. tuberculosis Δrv0455c mutant is hypersensitive to exogenous siderophores. a–d The indicated M. tuberculosis strains were grown in low-iron 7H9 medium for 5 days to deplete intracellular ...

The protein MmpL5 is an efflux transporter, a critical pump that helps the pathogen M. tuberculosis grow by scavenging essential iron. Unfortunately, overexpressed MmpL5 can also pump out ...

The Rv0455c protein of Mycobacterium tuberculosis, previously annotated as a protein of unknown function, has been shown to function in siderophore secretion. Siderophores acquire iron from the ...

Prior to Yu’s study, not much was known about the structure and function of the tuberculosis efflux pump regulator known as Rv3066. That, in part, is because researchers have attributed drug ...

A massive analysis of more than 10,000 different Mycobacterium tuberculosis bacteria isolates from 23 countries has revealed new genes associated with resistance to 13 first- and second-line new ...

Tuberculosis (TB) is a prevalent infectious disease that affects millions of people each year. It was previously the leading cause of death from a single pathogen before the COVID-19 pandemic.

Xin Wang et al, Engineered Mycobacterium tuberculosis triple-kill-switch strain provides controlled tuberculosis infection in animal models, Nature Microbiology (2025). DOI: 10.1038/s41564-024-01913-5 ...

Months- or even years-long regimens of potent antibiotics can eradicate the Mycobacterium tuberculosis bacteria. And in about 88% of cases globally, treatment is successful in curing the disease.

Tuberculosis (TB) bacteria appear in red inside a lung granuloma from a mouse infected with Mycbacterium tuberculosis, the bacterium that causes TB. A new genetic study of the bacterium in mice ...

Tuberculosis (TB) primarily affects the lungs, but the bacteria that causes TB can cause pus to collect in tissues. This is known as an abscess. Learn more here.