Figure 3: The triple-helix structure in TLC1 is not responsible ... The triple-helix region is in close proximity to the 3′ end of the DNA substrate. What chemical functional groups could ...

The structure described here contains ... The results presented here will allow better assessment of triple helix-forming propensities of DNA repeat sequences. They are also of value for the ...

This was the last structure pending to complete the atlas ... This therapeutic approach, which is based on DNA triple helix structures, would switch off the activity of the genes involved in ...

James Watson and Francis Crick proposed that DNA (deoxyribonucleic acid) was a double-helix structure, not a triple stranded structure as had been previously hypothesized, on April 2, 1953. The ...

Dervan of the California Institute of Technology independently demonstrated that the triple helix structure could indeed be exploited to design oligonucleotides (DNA strands about 15 nucleotides ...

A triple-helix DNA structure can form when certain nucleobases – pyrimidine or purine – occupy the major grooves in conventional B-DNA. This can happen naturally or as part of intentional ...

On February 28, 1953, James Watson and Francis Crick informally announced that they had discovered the double-helical structure of DNA ... making a triple helix), but they were prepared to ...

But James Watson and Francis Crick's claim was a valid one, for they had in fact discovered the structure of DNA, the chemical ... such a way to form a double helix, like a spiral staircase.

Certain DNA sequences can form structures other than the canonical double helix. These alternative ... the genome to go beyond sequence to include structure. "We hope our study will serve as ...

Rosalind Franklin’s role in the discovery of the structure of DNA may have been ... papers announcing the discovery of DNA’s double helix was published. Watson, Crick and Wilkins won the ...

known as a double helix, but it is possible for DNA to change shape and structure. The new study, published in Nature Communications, reveals the detail in the structure of a type of DNA called i ...