Transcription factors bind in a combinatorial fashion to specify the on-and-off states of genes; the ensemble of these binding events forms a regulatory network, constituting the wiring diagram ...

Other factors must also be involved in determining how strongly a transcription factor activates a gene. Glucocorticoid receptor is also a transcription factor One example is glucose production in the ...

Scientists at St. Jude Children's Research Hospital are exploring how a type of transcription factor called a pioneer transcription factor accesses DNA even when it is tightly wound. Their work ...

“Together with Roche's expertise, our objective is to successfully pursue challenging transcription factor targets, with the ultimate goal of providing novel interventions for patients who are ...

These TF-specific structural states may direct gene-specific regulatory events; in other words, Mediator—a general transcription factor—may acquire gene-specific functions that are triggered by TF ...

Our data suggest that transcription control by NFIs may be regulated by nuclear factor interactions with other TFs," states Dr. Helka Göös, the lead author of the study. The study provides the ...

The transcription factor FOXA1 has been one of the most coveted targets for a drug because it is implicated in the growth of breast and prostate cancers, according to Erb. Erb’s lab, in ...

Exploring the upstream transcription factors or proteins interacting with MdMYB10 is an important way to enrich the complex network of anthocyanin synthesis. In this study, the upstream regulatory ...