Hormone response elements for the thyroid receptor-α include specific distal 5′-flanking DNA Journal: Science Advances Published: 2024-11-29 DOI: 10.1126/sciadv.adr1033 Affiliations: 1 Authors: 4 ...

Best response in 32 evaluable patients who completed at least two cycles was 1 partial response (3%), 21 with stable disease (66%), and 10 with progressive disease (31%). The mean progression free ...

Notably, a metabolic complete response (mCR) was achieved in one patient with anaplastic thyroid cancer (ATC), the most aggressive form of the disease.

The classical model of gene regulation by hormones involves a hormone-bound receptor interacting with a DNA response element to increase or decrease gene transcription. Steroid hormone regulation ...

The investigators defined response as a 50% decrease in Hamilton Rating Scale for Depression (HAM-D) score. Remission occurred in 31 patients (58.5%) receiving T3 compared with 19 patients (38% ...

In the accompanying article to this editorial, Ho et al 2 aim to use the addition of the mitogen-activated protein kinase inhibitor selumetinib to improve the complete response rate in high-risk ...

SAN FRANCISCO — A novel thyroid receptor agonist — MGL-3196 — showed a sustained reduction in liver fat and other markers of nonalcoholic steatohepatitis in a 36-week study, according to ...