The centrally located DNA-binding domain is involved in recognition of thyroid hormone response elements in target gene promoters, and the N-terminal domain modulates gene expression. Current ...

Nuclear receptors bind to specific DNA sequences in the regulatory regions of their target genes known as response elements (see Figure 1). Some receptors, such as thyroid receptors, bind to DNA ...

However, tests of the humoral response, i.e. thyroid autoantibodies, can be assessed in most clinical laboratories. Unfortunately, the diagnostic and prognostic use of thyroid autoantibody ...

Regulation of Genes Coding for Cardiac Proteins by Thyroid Hormone ... in heart rate and left ventricular mass that improves in response to treatment with a β-adrenergic–receptor antagonist ...

as well as with thyroid gland-related issues. People with CFS also presented with low-grade inflammation, the body’s automatic response to any perceived harmful stimuli. However, this group of ...

Thyroid cancers appear to be dependent on RAF/MEK/ERK (MAPK ... The primary end point was objective response rate. The secondary end points were safety, overall survival, and time to progression. 32 ...

A 50-year-old woman with no notable medical history presented with a neck mass identified as a nodular infiltrating papillary thyroid carcinoma ... achieving a best response of stable disease. Her ...

Resistance developed in a patient with metastatic anaplastic thyroid carcinoma after an extraordinary 18-month response. Whole-exome sequencing of pretreatment and drug-resistant tumors revealed a ...

The extraordinary response of a woman against thyroid cancer is providing researchers with new insights on how best to fight against cancer. The thyroid cancer case involving 56-year-old Grace ...