Figure 3: Medulla–cortex re-organization after implantation of thymus epithelial grafts in vivo. Figure 4: Medullary islets arise in thymus stromal cell grafts generated from two different donor ...

Mainly composed of epithelial cells, lymphocytes, and dendritic cells, the thymus comprises two parts – medulla and cortex. The epithelial cells, known as TECs (thymic epithelial cells), are ...

In the normal thymus, TECs found in the cortex and the medulla are functionally distinct. For example, medullary epithelial cells are required for negative selection, failure of which leads to ...

The thymus is a soft gland with two lobes. Each lobe has a central par, known as the medulla, and an outer part, known as the cortex. It is large in infants and young children, but it decreases in ...

Lobules have two distinct areas: A dense outer cortex that is rich in actively dividing T-cells; An inner medulla, which is much paler in colour and functions as an area of T-cell maturation. In ...

The thymus is a much simpler organ and in these experiments became fully functional. Structurally it contained the two main regions - the cortex and medulla - and it also produced T-cells.

The cells in the medulla region of the thymus have a straightforward task: they are programmed to randomly display bouquets of proteins characteristic of various bodily tissues in order to "train ...