An improved understanding of thiopurine metabolism has enabled individualized dosing of these agents in patients with IBD. Ansari et al. describe the use of allopurinol to deliberately manipulate ...

Thiopurine metabolism and thiopurine methyl transferase (TPMT) enzyme activity assay. Azathioprine (AZA) is converted into 6-mercaptopurine (6-MP), which can also be administered as a parent drug.

Metabolite monitoring; NNT: Number needed to treat; QALY: Quality-adjusted life year; TPMT: Thiopurine S-methyltransferase. Disclosure: The authors have no other relevant affiliations or financial ...

Mayo Clinic researchers found that a gene variant, the TPMT∗8 allele, is associated with reduced metabolism of the thiopurine class of drugs. TPMT∗8 is relatively common in individuals of ...

Metabolism refers to how the drug gets broken ... Differential responses to thiopurine drugs provide a concrete example of why this is true. Thiopurine drugs are used to treat acute lymphoblastic ...