Here we study how the tertiary and quaternary structure of the mitochondrial translocator protein TSPO, which binds cholesterol with nanomolar affinity, is affected by this sterol. Residue ...

Protein folding is a process by which a polypeptide chain folds to become a biologically active protein in its native 3D structure ... proteins lose their tertiary and secondary structures ...

Anfinsen, based on his studies of the ribonuclease enzyme, proposed that all the information needed to determine the tertiary structure of a protein is encoded in its amino acid sequence. “It is ...

The stacking of these helices and sheets forms the tertiary structure. Protein folding must be maintained in their three-dimensional shape and should not aggregate or degrade. Unfolded or ...

The protein A10 ... interest in the structure of poxvirus core proteins, there remains a drought of experimentally determined structures. The team utilized the revolutionary AlphaFold software, which ...

There is some evidence that the membrane-bound protein is a receptor, with possible roles in cell adhesion or signaling. The secreted ectodomain of APP may function as a growth factor. A better ...

DeepMind has predicted the structure of almost every protein so far catalogued by science, cracking one of the grand challenges of biology in just 18 months thanks to an artificial intelligence ...

They knew its underlying chemical code. But the protein’s all-important 3D structure was eluding them. That shape was the key to developing the right vaccine to slide in and block the parasite ...