The team reported that the treatment has significantly cleared tau protein build-up and enhanced ... for non-invasive delivery of tau therapeutic antibodies directly to the brain, and it holds ...

Single IV administration of tau silencing gene therapy VY1706 significantly reduced tau mRNA and protein levels, with broad brain distribution ...

The neurotransmitter glutamate is essential for regulating everything from mood to memory, but it can also encourage a toxic buildup of the notorious tau protein, which can contribute to Alzheimer ...

transferred to nitrocellulose and stained with a human tau-specific polyclonal antibody (E1, aa 19–33) and with antibodies (WKS45, Tau46) that recognize both human and mouse tau. Antibodies ...

Neurofibrillary tangles (NFTs) are neurobiological lesions that are found in brain cells of patients with Alzheimer's disease (AD). They consist of aggregates of abnormally phosphorylated tau ...

Voyager Therapeutics (VYGR) reported new data from its two preclinical programs targeting tau for the treatment of Alzheimer’s disease. Data on ...

USC Stem Cell scientists discover a new way to rid cells of toxic tau protein in a study involving mice and lab-grown human “mini-brains,” known as organoids. The neurotransmitter glutamate is ...

Key protein identified for understanding and treating Alzheimer's disease Date: February 28, 2025 Source: University of Cologne Summary: Researchers have identified a specific form of the tau ...

Many proteins group together in what are called protein complexes to carry out biological functions. The traditional method of generating antibodies by immunizing animals struggles to make ...

This could only be rescued with antibodies directed against the MTBR and C-terminal-adjacent regions, implicating these tau species in synaptotoxicity. Tau fragments from trisomy 21 neurons inhibited ...

Antibodies that bind the N-terminal of tau ... and resulted in dose-dependent knockdown of tau mRNA (44% to 73%) and tau protein (27% to 55%) broadly across the brain. Voyager anticipates filing ...