A special group of immune cells known as regulatory T cells, or Tregs for short, became an overnight sensation when a trio of ...

Researchers have identified how to encourage tumors to build their own immune hubs—structures that look and function like lymph nodes—deep in the middle of cancer. Such immune hubs, known as tertiary ...

These blood vessels functioned like dedicated gateways, enabling large numbers of T and B cells to enter the tumors and assemble into TLSs. Within these TLS, B cells initiated germinal‑center ...

Nobel laureate Shimon Sakaguchi reflects on the role of regulatory T cells in peripheral immune tolerance and how the cells ...

This review uncovers how aging reshapes immunoglobulins, particularly IgG, IgM, and IgA, driving inflammation, cellular senescence, and tissue degeneration. By dissecting B-cell dysfunction, ...

The U.S. Food and Drug Administration (FDA) has granted fast track designation to UB-VV111 for the treatment of ...

MIT and Harvard scientists have created engineered CAR-NK cells that can hide from the immune system and more effectively destroy cancer. The cells are designed to suppress immune-rejection signals ...

Greater than 90% depletion of B cells within 12 hours of a single dose of AAN-14xMultiple redosing of AAN-14x at desired intervals with no evidence of hepatic or other toxicityRemarkable tumor ...