Synaptic vesicle exocytosis is the biological process by which a synaptic vesicle fuses with the plasma membrane of the pre-synaptic axon terminal and releases its contents into the synaptic cleft ...

Synaptic vesicle recycling has been studied for over three decades 3,4.In the best documented model of neurotransmitter release, the synaptic vesicle membrane undergoes exocytosis by collapsing ...

Interactions of two voltage-gated calcium channels and a pump enable separate control of exocytosis and endocytosis at chemical synapses. Chemical synapses transmit information within the nervous ...

When a stimulus arrives at the presynaptic terminal releases a vesicle by exocytosis. But to prevent the terminal to run out vesicles, immediately after exocytosis, occurs endocytosis.

The extra membrane is then captured in a process called endocytosis and recycled to form a new vesicle to enable the next cycle of release. Most important, exocytosis must be tightly coupled with ...

Synaptic Menagerie. Tau contacts all the synaptic vesicle proteins shown, except synaptobrevin, reinforcing the idea that it helps regulate exocytosis. [Courtesy of Tracy et al., Cell.] Most previous ...

A new study reveals how restoring α-synuclein levels can help preserve synaptic vesicle composition and function, offering therapeutic insights for Parkinson’s and other neurodegenerative diseases.

Reference: Gallimore AR, Hepburn I, Georgiev SV, O. Rizzoli S, De Schutter E. Dynamic regulation of vesicle pools in a detailed spatial model of the complete synaptic vesicle cycle. Sci Adv.

The reconstructed vesicle cycle model provides critical insights into synaptic transmission, advancing neuroscience and potential therapeutic applications.

More information: Andrew Gallimore et al, Dynamic Regulation of Vesicle Pools in a Detailed Spatial Model of the Complete Synaptic Vesicle Cycle, Science Advances (2025). DOI: 10.1126/sciadv.adq6477 .

Reference: Gallimore AR, Hepburn I, Georgiev SV, O. Rizzoli S, De Schutter E. Dynamic regulation of vesicle pools in a detailed spatial model of the complete synaptic vesicle cycle. Sci Adv.

07/19/2021 12:18 Mechanisms to separately regulate synaptic vesicle release and recycling Kathrin Voigt Kommunikation und Presse Johannes Gutenberg-Universität Mainz. Interactions of two voltage ...