The most accessible sensory nerve for biopsy is the sural nerve located behind the ankle. The procedure involves injection of a local anesthetic in the area to be biopsied. An incision about two ...

Nerve and muscle biopsy are occasionally performed to exclude infiltrative neoplasms, paraproteinemic vasculitis, or AL. If vasculitis is suspected, biopsy of the sural nerve is indicated.

We sought to determine whether early nerve damage may be detected by corneal confocal microscopy (CCM), skin biopsy, and neurophysiological tests in 86 recently diagnosed type 2 diabetic patients ...