In a recent study published in Progress in Neurobiology, researchers discover that the substantia nigra of individuals with Parkinson’s disease had a higher concentration of pheomelanin, as well ...

Parkinson’s disease is a neurodegenerative disorder characterized by loss of dopamine neurons in the substantia nigra and widespread accumulation of misfolded α-synuclein and Lewy bodies in the ...

The substantia nigra is a motor nucleus located in the basal ganglia of the midbrain. This brain structure contributes to the body's cognitive and motor functions by sending signals to initiate or ...

Deep in the human brain, a very specific kind of cell dies during Parkinson’s disease. For the first time, researchers have sorted large numbers of human brain cells in the substantia nigra into ...

After stereotactic injection of ATB NPs into the substantia nigra of PD mice, the ATB NPs anchored to the surface of dopaminergic neurons via the TRPV1 antibody. Under 808 nm pulsed near-infrared ...

Steeling for a Possible Iron-Parkinson Connection Courtesy of Kurt Jellinger IF IT ONLY WERE ELEMENTARY: Element distribution found by energy dispersive x-ray analysis in neuromelanin from nigral ...

Journal reference: Luppi, M.P., et al. (2021) Sox6 expression distinguishes dorsally and ventrally biased dopamine neurons in the substantia nigra with distinctive properties and embryonic origins.

Macosko’s team looked at cells from the substantia nigra of eight people who didn’t have Parkinson’s and had agreed to donate their brains for research after death. The researchers used a ...

For the current study, Awatramani and colleagues performed immunofluorescence staining on post-mortem samples of substantia nigra from patients with Parkinson's disease and discovered that ventral ...