In this context, we will highlight select examples that exploit the Lewis acidity, organometallic reactivity and small-molecule activation modes of metal ions for chemoselective fluorescent probe ...

"The advantages of a fluorescence probe ... NIR small-molecule dye approved by the FDA for use as a contrast agent. A longer lifespan means researchers have more time to record the fluorescent ...

Distinguishing B cells from T cells using an SLC35C2 transporter-targeting fluorescent probe ... successfully developed a small molecule probe CDyB (which stands for Compound of Designation ...

For example, the bioactive small ... a parent molecule that would naturally bind to a protein, and the photoreactive group reacts to ultraviolet light irradiation that activates the probe.

but show a bright fluorescent glow when treated with (S)-PHA533533, indicating that the small molecule potently activated the dormant paternal allele of UBE3A. [Vihma et. al 2024] Researchers were ...

For no clear reason, it draws a distinction between large and small molecule medicines. As part of the IRA’s Medicare price control provisions, price negotiation for small molecule medicines is ...

To create a fluorescent probe for glutathione detection, Professor Rafael Luque, director of Scientific Centre of Molecule Design and Synthesis of Innovation Materials for Medicine of United Institute ...

“Today’s two presentations highlight the unique potential of VG-3927 as an orally bioavailable, highly potent and CNS penetrant small molecule TREM2 agonist and provide the complete dataset ...

The modulation of RNA splicing by small molecules has emerged as a promising strategy for treating pathogenic infections, human genetic diseases, and cancer; however, the principles by which ...

A team led by UNC School of Medicine researchers is the first to confirm that a small molecule called miR-29 plays a role in driving aging. Their new findings are published in Communications Biology.