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What is rapamycin? Devotees claim the drug can slow aging
Also known as sirolimus or Rapamune, rapamycin inhibits the activity of a protein called mTOR, which helps regulate cell growth and metabolism. Suppressing mTOR seems to weaken inflammation and ...
Nature12y
Efficacy of the investigational mTOR kinase inhibitor MLN0128/INK128 in models of B-cell acute lymphoblastic leukemia
The mechanistic target of rapamycin (mTOR) is a serine/threonine kinase whose activity contributes to leukemia proliferation and survival. Compounds targeting the mTOR active site inhibit ...
Monthly Prescribing Reference4d
Encapsulated Rapamycin Fast Tracked for Familial Adenomatous Polyposis
The Fast Track designation is supported by data from a phase 2 trial that evaluated eRapa in 30 adult patients with FAP.
Following Positive Phase 2 Results and Orphan Drug Designation, Biodexa's FAP Drug Receives FDA Fast Track Status
CARDIFF, UK / ACCESS Newswire / February 12, 2025 /Biodexa Pharmaceuticals PLC. (NASDAQ:BDRX), a clinical-stage ...
Medscape12d
Mammalian Target of Rapamycin: Biological Function and Target for Novel Anticancer Agents
2010;67(24):2095-2106. Temsirolimus is primarily metabolized by the cytochrome P-450 (CYP) 3A4 isoenzyme to five major metabolites, with sirolimus being the principal active metabolite.