One common symptom is the thickening and tightening of the skin, which can affect not only appearance but also mobility.

But how much do we really know about this condition? What are its symptoms, diagnosis, and treatment? In this gallery, you'll ...

HEALTH Scleroderma: The disease that Bob Saget fought to find a cure for after it took his sister’s life Scleroderma Research Foundation: 'Bob was a champion for scleroderma patients everywhere' ...

Scleroderma is a rare autoimmune disease characterized by skin tightness, thickening and inflammation, but the condition can also affect the lungs, throat, heart, kidneys and intestines, among ...

But what exactly is scleroderma and why did Saget support the foundation? Following the death of “America’s favorite dad,” Bob Saget, 65, on Sunday, many close to him ...

Investigational interstitial lung disease (ILD) drug, efzofitimod, shows early signs of efficacy in patients with pulmonary ...

"Scleroderma has several subsets, so that it's difficult to make sweeping generalizations," he says. "However, the vast majority of its manifestations are treatable, and most people do well.

Kristine has a fatal form of scleroderma that attacks her organs. "The fatality, they said it can happen probably about 10 years after you get diagnosed," Kristine said. "It's like cobwebs in my ...

Bob Saget was a tireless activist for the Scleroderma Research Foundation, inspired by the death of his sister, Gay Kate Hogan is Director of Digital Specials and Features at PEOPLE, as well as ...

A 35-year-old patient with a history of more than 10 years of scleroderma presented with intolerable finger pain and progressive digital gangrene. How should he be treated?

Scleroderma, an auto-immune disease, causes the body to produce too much of the structural protein collagen. The sufferer's own immune system attacks healthy organs, thinking they are diseased ...