Despite great advances in recent decades, the pathogenesis and pathophysiology of SLE, above all the etiology ... various signaling molecules, including TLR ligands, IL-21 and BAFF.

In addition, genes with unknown roles in SLE pathophysiology have been identified ... Toll-like receptor (TLR) function and type I interferon production; and immune signal transduction in lymphocytes.

When the pathogen-sensing intracellular receptors TLR-7 and TLR-9 were implicated in systemic lupus erythematosus (SLE), it was suspected that their removal would lessen the severity of the disease.

pathophysiology, disease classification and staging systems and epidemiology. It also helps in visualizing the composition of the Systemic Lupus Erythematosus (SLE) market in terms of dominant ...