From November 2022 to August 2023, DEFENDER randomized 507 critically ill adults with acute organ dysfunction at 22 ICUs in Brazil to either standard care plus oral dapagliflozin ...

About The Study: The addition of dapagliflozin, a sodium-glucose cotransporter 2 inhibitor, to standard care for critically ill patients and acute organ dysfunction did not improve clinical ...

Before death, the most common organ dysfunction was pulmonary (81.7%), neurologic (57.3%) and renal (39%). Mechanical ventilation was used in 74.4% of patients during hospitalization.

Acute-on-chronic liver failure (ACLF) ... However, this catabolism depletes peripheral organs, contributing to muscle wasting, mitochondrial dysfunction, and organ failure.

Men with acute COVID-19 were found to have hormonal imbalances indicating possible primary testicular damage. The underlying mechanism of SARS-CoV-2 action on the gonads remains unclear.