Down syndrome, which causes a range of developmental differences and affects 1 in 700 newborns in the United States, is caused by the presence of an extra copy of chromosome 21. Mongkolchon ...

High p-tau217 and GFAP levels predicted future amyloid buildup. Down syndrome-related Alzheimer's disease is now considered a genetically determined form of Alzheimer's.

Many scientists view Down’s syndrome as a genetic form of Alzheimer’s because the amyloid precursor protein (APP) gene lies on chromosome 21. The extra dose of APP in DS causes amyloid to amass in the ...

Down syndrome with Alzheimer's disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis. Alzheimer's & Dementia, 2025; 21 (6) DOI: 10.1002/alz.70322 ...

More information: Benjamin J Buehner et al, Medial temporal lobe atrophy in Down syndrome along the Alzheimer's disease continuum, Brain (2025). DOI: 10.1093/brain/awaf133 ...