OBJECTIVE: To investigate whether retinoid X receptor agonists act as insulin sensitizers and compare their effects with that of thiazolidinedione BRL 49653 in obese Zucker rats. DESIGN: In two ...

The present study determined the influence of a retinoid X receptor agonist bexarotene on angiogenesis and metastasis in solid tumours. In the experimental lung metastasis xenograft models ...

7157 Background: Gefitinib (Iressa) is an orally active epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) approved for the treatment of advanced non-small cell lung cancer (NSCLC).

A regulator of gene expression, retinoid X receptor (RXR), can boost scavenging cells in their mission to clear the brain of dead cells and debris after a stroke, thus limiting inflammation and ...

Cooperative antitumor activity between the retinoid X receptor (RXR)-selective agonist bexarotene and EGFR-tyrosine kinase inhibitors in preclinical models of NSCLC. JCO 24 , 17073-17073 (2006). DOI: ...

A regulator of gene expression, retinoid X receptor (RXR), can boost scavenging cells in their mission to clear the brain of dead cells and debris after a stroke, thus limiting inflammation and ...

The action of a nuclear receptor (NR) is determined by the balance between corepressors and coactivators. These receptors (bound to DNA as heterodimers with the retinoid X receptor or as ...

New preclinical research led by Jarek Aronowski, MD, PhD, of The University of Texas Health Science Center at Houston (UTHealth) shows that retinoid X receptor (RXR) can boost recovery after a stroke.

Topical retinoids (for example, tretinoin) and retinoid analogues (for example, adapalene and tazarotene) help normalize hyperkeratinization and have demonstrated significant anti-inflammatory ...