Rectal cancer diagnoses account for nearly one-third of colorectal cancers, and more than 46,000 adults in the U.S. are estimated to be diagnosed with this disease in 2024.

The National Comprehensive Cancer Network mirrored the definition when, for the first time, it recommended watch-and-wait as an option for near-complete response in its 2023 rectal cancer guidelines.

Rectal cancer kills around 4,100 people in the UK (around 410 in Scotland) every year. Over the last 20 years, the incidence of early-onset rectal cancer has increased by 50.5% in the UK (53.6% in ...

All patients were expected to exhibit cCR at the time of reassessment of response based on previous attempts to standardize clinical endoscopic features of a cCR as described elsewhere. 15 In addition ...

More information: Charles J. Kahi et al, Rectal Location and Postcolonoscopy Colorectal Cancer Outcomes, JAMA Network Open (2025). DOI: 10.1001/jamanetworkopen.2025.13391 ...

METHODOLOGY: Tumor deposits negatively impact colon cancer survival, but the AJCC tumor, lymph node, and metastasis (TNM) staging system only considers these deposits in the absence of positive ...