The expression of recombination-activating gene (RAG) proteins is required for the rearrangement of immunoglobulin genes and receptor editing in immature B cells in the bone marrow. However ...

The authors generated mutant mice in which the RAG proteins could interact with and bind to DNA normally without initiating V(D)J recombination and assessed RAG protein binding, as well as the ...

A “complete eradication” of B cells with chimeric antigen receptor T-cell therapy is responsible for the long-term, drug-free remission from autoimmune diseases observed after treatment ...