Artificial biosynthetic pathways are typically assembled and optimized progressively, from earlier to later steps. This commentary highlights the potential of an alternate regressive method for ...

Biosynthetic pathways for secondary metabolites usually make many products, not just one. In this Commentary, we consider why molecular promiscuity might be an evolutionarily advantageous feature ...

Anabolic – this type of pathway requires energy and is used to build up large molecules from smaller ones (biosynthesis). Catabolic – this type of pathway releases energy and is used to break ...

This pathway involves the conversion of simple precursor molecules ... are used as immunosuppressive drugs to treat autoimmune disorders like rheumatoid arthritis and multiple sclerosis. These drugs ...