Because these strains are unlikely to contain segregating alleles of large effect at every locus contributing to variation in natural populations, some loci will remain undetected. Furthermore ...

(A) Quantitative trait locus (QTL) mapping requires parental strains (red and blue plots) that differ genetically for the trait, such as lines created by divergent artificial selection.

Deep learning and ATAC-seq uncover noncoding variants linked to gene regulation and disease in human liver cells.