Pyruvate formate-lyase (PFL) from Escherichia coli uses a radical mechanism to reversibly cleave the C1-C2 bond of pyruvate using the Gly 734 radical and two cysteine residues (Cys 418, Cys 419). We ...

This is a preview. Log in through your library . Abstract The mitogenic lectins concanavalin A and phytohemagglutinin were found to stimulate pyruvate oxidation in rat mesenteric lymphocytes. Marked ...

We show that the M2 isoform of pyruvate kinase (M2PYK) exists in equilibrium between monomers and tetramers regulated by allosteric binding of naturally occurring small-molecule metabolites.

The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark ...

Cancer cells are known to favor aerobic glycolysis for energy production, a phenomenon termed the Warburg effect. This metabolic shift is essential for tumor growth, supplying energy, metabolites, and ...

Acetolactate synthase, also known as acetohydroxyacid synthase (AHAS), is an enzyme involved in the branched chain amino acid biosynthesis pathway. AHAS is a thiamine diphosphate (ThDP)-dependent ...