This behavior is difficult to explain if prions are not made of prion protein. PrPSc molecules can bind to PrPC molecules in the test tube and convert them to the abnormal (PrPSc) conformation.

Almost two decades have passed since Stanley Prusiner proposed that the transmissible agent causing spongiform encephalopathies consists of a misfolded protein — but the biology of prion ...

The molecule is miR-519a-3p, a microRNA directly linked to the expression of the cellular prion protein (PrPC), which is deregulated in people suffering from some neurodegenerative diseases such ...

In TSEs the normal cellular prion protein (PrP C) is transformed into an infectious disease ... injected anti-PrP monoclonal antibodies with high affinity for both murine PrPC and PrPSc into ...

To understand the importance of the prion protein in cancer biology, it is first necessary to understand the mechanism of action of glioblastoma. As Lopes explains, surgery and treatment with ...

The findings are published in the journal BMC Cancer. In the study, the team discovered that the prion protein plays a key role in the biology of glioblastoma. "The treatment of glioblastoma has ...

A system for the rapid amplification of misfolded prion oligomers provides new evidence supporting the prion hypothesis and may offer a powerful diagnostic tool. The prion hypothesis remains ...