EXPORT MECHANISM: The tRNA must mature inside the nucleus before export. tRNAs are aminoacylated, and only tRNAs charged with an amino acid are exported efficiently. Export occurs when the tRNA is ...

A series of structures of the eukaryotic protein-synthesis machinery are imaged at high resolution in defined states of the elongation phase of protein synthesis. Analysis suggests that there are ...

Researchers demonstrated how amino acids could spontaneously attach to RNA under early Earth-like conditions using thioesters, providing a long-sought clue to the origins of protein synthesis. This ...

Scientists from Uppsala University have used cryo-electron microscopy to reveal details of the protein synthesis mechanism in the parasite Giardia intestinalis, which causes diarrhoeal disease. The ...

New research shows how pseudorabies virus protein VP22 hijacks DDX21 to inhibit cGAS activation, weakening type I interferon ...

Scientific breakthroughs have accelerated the pace at which new pharmaceuticals are being developed. Tierra Biosciences thinks that pace can go faster. The San Leandro-based company has developed a ...

Bacteriophages — viruses that infect bacteria — are locked in a constant arms race with their microbial hosts. A family of phages known as jumbo phages have evolved a remarkable strategy of building a ...