This finding reveals how striatal spiny projection neurons operate on a "use it or lose it" basis, weakening synapses that were not actively involved in controlling behavior, Surmeier said.

More information: Patricia Bonnavion et al, Striatal projection neurons coexpressing dopamine D1 and D2 receptors modulate the motor function of D1- and D2-SPNs, Nature Neuroscience (2024). DOI ...

Study uncovers how gradual CAG repeat expansion in neurons drives the onset of Huntington’s disease, offering new insights for potential therapeutic interventions. Study: Long somatic DNA-repeat ...

Neurons are the cells that govern brain function, and you are born with most of the neurons you will ever have during your lifetime.While the brain undergoes most of its development during early ...