According to Gentile, the cell line routinely achieves yields exceeding 4×10¹⁴ vector genomes per liter (vg/L) across a range of serotypes, which are levels comparable to leading commercial ...

Human embryonic kidney (HEK293) cells are the most commonly used cell line to produce viral vectors for gene therapy. Due to the complexity of their production and purification, viral vectors can be ...

Early work on continuous, high-titre vector production established efficient systems for the stable expression of essential viral proteins, thereby setting benchmarks for yield and reproducibility ...