The prion protein forms functional condensates that are enriched at cell-cell interfaces. However, long exposure to copper ions/hydrogen peroxide that result in oxidative stress, triggers a liquid ...

The group then studied the interaction of prion with the CD44 protein, a well-known cancer stem cell marker involved in the collective invasion of breast and colon cancers.

August 24, 2010 — A novel sporadic prion protein disease, variably protease-sensitive prionopathy (VPSPr), with distinct features has been described as the first new prion disease since sporadic ...

Interestingly, the disordered region, the so-called N-terminal domain of the prion protein, has developed differently in mammals than in amphibians. This suggests a new function for mammalian PrP ...

Scientists at Northwestern University and University of California, Santa Barbara have created the first synthetic fragment of tau protein that acts like a prion. The “mini prion” folds and ...

Correspondence Detection of Prion Protein Seeding Activity in Tear Fluids Published May 10, 2023 N Engl J Med 2023;388: 1816 - 1817 DOI: 10.1056/NEJMc2214647 ...

The 180-degree twist in the protein is the “most dramatic difference,” Caughey says. Rodent-adapted versions also have some loops that the deer prion lacks, or that “are all convoluted by ...

A new epigenetic editing tool shows promise as a therapy for prion disease. The approach for silencing prion protein (PrP), is both specific and can lead to wide-spread knockdown expression of PrP ...

First synthetic 'mini prion' shows how protein misfolding multiplies Model enables study of fundamental interactions underlying neurodegenerative disease Date: April 30, 2025 Source: Northwestern ...