They found that the prion-domain of Sup35 acts like a stress sensor that triggers the formation of protective protein droplets and gels when cells are exposed to harsh conditions. When cells are ...

Released by astrocytes, stress-inducible phosphoprotein 1 (STI1 ... Because STI1 binds to the same vicinity in cellular prion protein as does Aβ (see Lopes et al., 2005), Prado and colleagues wondered ...

Sometimes compared to Dr. Jekyll and Mr. Hyde, the original prion protein identified by Prusiner as being responsible ... Other factors, such as cellular stress and the aging process also are thought ...

Scientists at Northwestern University and University of California, Santa Barbara have created the first synthetic fragment of tau protein that acts like a prion. The "mini prion" folds and stacks ...

Jiyan Ma, Howard Hughes investigator at the University of Chicago, and Susan Lindquist, who directs the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, are proposing a ...

A new study suggests that the normal form of prion protein helps maintain the insulation that speeds electrical signals along nerve fibers. In its twisted Mr. Hyde form, the prion protein causes ...

It turns out both diseases involve something called a prion protein. The finding, which appears in the journal Nature, could explain one of the great mysteries in Alzheimer's disease: How ...

Scientists at Northwestern University and University of California, Santa Barbara have created the first synthetic fragment of tau protein that acts like a prion. The “mini prion” folds and stacks ...

Prion diseases are a group of rare, invariably fatal brain diseases that occur both in humans and animals. They are caused by the presence of an abnormal protein in the brain tissue, called scrapie ...

The findings are published in the journal BMC Cancer. In the study, the team discovered that the prion protein plays a key role in the biology of glioblastoma. "The treatment of glioblastoma has ...