Taken together, the results identify the biophysical conditions and mechanisms for copper-induced prion protein misfolding, clumping and neurotoxicity, the researchers wrote. Related: Prion trials and ...

Targeting cellular structures called nuclear speckles could be a completely new approach for treating ...

A groundbreaking study reveals that reshaping nuclear speckles — tiny structures inside cell nuclei that regulate protein maintenance — could be a novel way to treat proteinopathies like Alzheimer’s, ...

Prion diseases, also known as TSEs, are a transmissible protein misfolding disease, which makes them a good model to study common aspects of these diseases.

"Size of protein aggregates, not abundance, drives spread of prion-based disease." ScienceDaily. ScienceDaily, 1 November 2010. <www.sciencedaily.com / releases / 2010 / 10 / 101028141751.htm>.

Prion Protein Modulates Monoaminergic Systems and Depressive-like Behavior in Mice. Journal of Biological Chemistry, 2015; 290 (33): 20488 DOI: 10.1074/jbc.M115.666156 ...

In an article entitled "Prion protein modulates monoaminergic systems and depressive-like behavior in mice" and published in the Journal of Biological Chemistry, the group shows that mice lacking ...

Other plant scientists whom Nature contacted consider this idea to be extremely speculative. But, “it would be really cool to find that prion-like behaviour is playing a role in some normal ...

♦ A fluorescence-based technique that identified misfolded prion proteins with single-molecule sensitivity and determined the role of metal ions in misfolding. The researchers used this technique to ...

Prion aggregates that remain small are transmitted with greater efficiency. "In this paper we changed the transmissibility just by shifting the size," Serio said.