A prime example of proteins that catalyze their own conformational change into the toxic form is the prion proteins ... to the prevention of protein misfolding. Despite chaperone actions, some ...

also called Creutzfeldt-Jakob disease (CJD), results from the misfolding of a normal prion protein—an essential protein present in everyone. The misfolded form of the protein, the cause of CJD ...

They can be genetic, sporadic—without known cause—or acquired, in which exposure to abnormal prion protein induces misfolding of the host’s own normal prion proteins. While prion disorders like ...

Saborio, G.P. et al. Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding. Nature 411, 810–813 (2001).

The US Centers for Disease Control and Prevention defines two types of CJD: classical, which generally arises through spontaneous protein misfolding in the brain, and variant CJD (vCJD), which is ...

The Kane research laboratory will focus on chronic wasting disease (CWD) and translate these findings to other protein misfolding diseases ... Additionally, Dr. Kane aims to extend prion biology ...