G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

G beta-gamma (purple circles), and a G-protein-coupled receptor (GPCR; light green loops). Upon receptor stimulation by a ligand called an agonist, the state of the receptor changes. G alpha ...

Researchers were able to observe, at an atomic scale and in real time, how membrane lipids interact with G protein-coupled receptors ... These newly identified pathways could be leveraged to ...

The 2012 Nobel Prize for Chemistry has been awarded to Robert Lefkowitz and Brian Kobilka for groundbreaking discoveries that reveal the inner workings of G-protein-coupled receptors. Professor David ...

"Although the contribution of G-protein-coupled receptors (GPCRs ... cancer stemness and cancer associated signaling pathways. Indeed, big data population analyses indicate the significance ...