Scientists aim to repair or replace p53 to combat cancer
Cancer arises when your cells grow uncontrollably and refuse to die when they should. Normally, your body is equipped with ...
Hosted on MSN10mon
The architectural role of p53: Early 3D chromatin remodeling to trigger cellular stress response
Scientists certainly know a lot about p53. It starts a broad cascade of events inside the cell, involving the activation of hundreds of other genes, that will collectively try to control damage or ...
Nature7mon
ATM: the p53 booster
The different serine phosphorylation sites in the p53 protein may be the 'sensors' that choose which target genes become activated. The amount and type of DNA damage and the subsequent activation ...
Medscape2mon
Lung Cancer Pathogenesis Associated With Wood Smoke Exposure
The aim of the present work was to establish an association between wood smoke exposure and lung cancer pathogenesis, and to analyze the effects of wood smoke on p53 and murine double minute 2 ...
The Scientist1y
Avoiding Gene Editing’s Unintended Consequences
The researchers also saw significant overexpression of two gene modules in these cells: the p53 DNA damage response and general ... CRISPR editing occurred after T cell activation and stimulation. In ...