Scientists certainly know a lot about p53. It starts a broad cascade of events inside the cell, involving the activation of hundreds of other genes, that will collectively try to control damage or ...

The different serine phosphorylation sites in the p53 protein may be the 'sensors' that choose which target genes become activated. The amount and type of DNA damage and the subsequent activation ...

The aim of the present work was to establish an association between wood smoke exposure and lung cancer pathogenesis, and to analyze the effects of wood smoke on p53 and murine double minute 2 ...

The researchers also saw significant overexpression of two gene modules in these cells: the p53 DNA damage response and general ... CRISPR editing occurred after T cell activation and stimulation. In ...

Additionally, RNA sequencing databases containing high-fat diet-fed P53-knockout mice and human MASLD samples were utilized.