Accumulation of a protein called TDP-43 is a key feature of ALS and frontotemporal dementia. In a newly published study, ...

The authors make the credible point that computational structure simulations are still necessary and useful, even though the structure of the normal prion protein was solved by nuclear magnetic ...

"Scrapie" is the old Scottish shepherds' name for a disease of their sheep which has been known for several centuries. It is the original example of a group of diseases, known as the ...

They can be genetic, sporadic—without known cause—or acquired, in which exposure to abnormal prion protein induces misfolding of the host’s own normal prion proteins. While prion disorders like ...

also called Creutzfeldt-Jakob disease (CJD), results from the misfolding of a normal prion protein—an essential protein present in everyone. The misfolded form of the protein, the cause of CJD ...

Under normal circumstances ... (a condition where multiple phosphate groups are added to the protein), by prion self-catalytic conformational conversion, or by mutations that make the protein ...

In TSEs the normal cellular prion protein (PrP C) is transformed into an infectious disease-associated isoform, PrP Sc — a potential target for immunotherapy. In the March 6 Nature, Anthony R. White ...