The Hsc70 system maintains the synaptic SNARE protein SNAP-25 in an assembly-competent state and delays its aggregation. Journal of Biological Chemistry, 2024; 300 (12): 108001 DOI: 10.1016/j.jbc ...

The team dug deeper and observed not only that Hsc70 helps in forming SNARE, it actually combines with SNAP-25 into a protein complex. That complex is what keeps SNAP-25 in the correct form for SNARE.

UMass researchers highlight role ‘workhorse protein’ plays in keeping the nervous system running smoothly The research breakthrough details one of the key steps in neurotransmission Peer ...

The team dug deeper and observed not only that Hsc70 help in forming SNARE, it actually combines with SNAP-25 into a protein complex. That complex is what keeps SNAP-25 in the correct form for SNARE.

New research now gives us an atomic-scale picture of signaling in neurons. Led by recent Nobel laureate Thomas Südhof, scientists are piecing together how the protein devices in synapses work ...