Glutamate receptors, including AMPA and NMDA subtypes, are pivotal mediators of excitatory transmission and plasticity across the mammalian central nervous system. Their regulation, which involves ...

Three distinct snapshots obtained with cryo-electron microscopy illustrate the arrangement of two of the four symmetrical subunits that make a functional NMDA receptor. During activation, as the ...

This project will investigate how residues located in the cytoplasmic domain of NMDA receptors influence this receptor's function. Approaches include mutagenesis, protein expression in heterologous ...

“The findings of the present study reveal that aging is linked to a decline in serine racemase protein levels across various brain regions [...]” Aging is associated with a decrease in ...

Researchers from the Institute for Neurosciences (IN), a joint center of the Miguel Hernández University of Elche (UMH) and the Spanish National Research Council (CSIC), who are also part of the ...

Arialys Therapeutics Publishes Preclinical Data in Nature Communications Supporting ART5803 as a First-in-Class Precision Therapeutic for Anti-NMDA Receptor Autoimmune Neuropsychiatric Disease Study ...

In a recent study published in Nature, researchers developed the MK-801 bimodal drug that successfully cures obesity, hyperglycemia, and dyslipidemia in mouse models of metabolic illness by combining ...

Please provide your email address to receive an email when new articles are posted on . Cognitive recovery was greatest within the first 6 months of diagnosis, persisting up to 36 months. After the 36 ...

For 1 week, a 34-year-old woman complained of headache, feeling feverish, and being unsure of herself. She attributed these symptoms to stress and anxiety and took two of her husband's alprazolam ...

The brain’s cerebellum plays a key role in coordinating movement, balance, and cognition. Injury to the cerebellum can have a profound impact on basic motor skills, such as sitting, standing, and ...

When it comes to brain proteins, small changes can make a dramatic difference. Researchers studying NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment ...