A class of drugs called NMDA (N-methyl-D-aspartate) receptor antagonists may be an option for people with MDD who don’t feel better with conventional antidepressant treatment. Research shows ...

Accordingly, structural and functional impairment of the NMDA receptor can lead to neurodegenerative and cognitive disorders, including Alzheimer’s disease, Parkinson’s disease, Huntington's ...

NMDA (short for N-methyl-D-aspartate) receptor antagonists are a class of drugs that may help treat Alzheimer's disease, which causes memory loss, brain damage, and, eventually, death. There's no ...

A reduction in surface-expressed NMDA receptors was also found in neuronal cultures prepared from mice bearing APP with the familial Swedish mutation, with no change in total receptor amounts.

A research team has identified a molecular mechanism that coordinates the operation of the N-methyl-D-aspartate (NMDA) glutamate receptor, which is key to regulating excitatory synapse function in ...

Dextromethorphan-bupropion is an oral N-methyl D-aspartate (NMDA) receptor antagonist, and "represents the first new oral non-monoamine-based mechanism of action approved to treat major depressive ...

Ketamine has received a Hollywood makeover. It used to be known as a rave drug (street name special K) and cat anesthetic. However, in recent years, some doctors have prescribed ketamine to treat ...

REL-1017 is a novel N-methyl-D-aspartate receptor (NMDAR) channel blocker. The investigational treatment is administered orally once daily and is designed to target hyperactive GluN1-GluN2D NMDAR ...

Anti-NMDA receptor encephalitis is an acute disease occurring when antibodies produced by the body's own immune system attack N-methyl-D-aspartate (NMDA) receptors in the brain. Recovery from this ...

Thirteen percent of patients with definite anti-N-methyl-D-aspartate receptor encephalitis (ANMDARE) have suicidal thoughts and behaviors during the acute phase of the disease, according to a ...