Combining methadone with other long-acting and short-acting opioids for pain management. Ask the Experts about Pharmacotherapy. Medscape Pharmacists. Posted 03/02/2006. Available at: https ...

The chemical similarity comparison also identified groups of receptors that were unrelated by sequence and structure ... methadone, which is known to act at NMDA (N-methyl-D-aspartate) and μ ...

as well as its partial agonist effect on the mu-opioid receptor or MOP, positions it as a promising non-opioid alternative to current treatments like methadone and buprenorphine. The preclinical ...