The mu-opioid receptor (MOR), has a critical role in the hedonic and consummatory aspects of ingestive behaviour. 1 In animals, MOR agonism enhances hedonic reactions to highly palatable foods and ...

Methylnaltrexone (MNTX) is approved in the USA and more than 50 other countries for treatment of opioid induced constipation (OIC). MNTX works by binding to the mu opioid receptor (MOR) in ...

Mu-Opioid Antagonist Effective for Drug-Induced Constipation — But questions remain about whether the need is currently unmet by Pippa Wysong, Contributing Writer, MedPage Today February 23, 2016 ...

ALKS 5461 consists of a fixed-dose combination of buprenorphine, a partial mu-opioid receptor agonist and kappa-opioid receptor antagonist, and samidorphan, a mu-opioid receptor antagonist.

Opioids are compounds that resemble opium in their addictive characteristics and psychological effects. Opioids are medications that relieve pain by reducing the intensity of the pain signals ...

The opioid system controls pain, reward and addictive behaviors. Opioids exert their pharmacological actions through three opioid receptors, mu, delta and kappa whose genes have been cloned (Oprm ...

e13597 Background: Expression of the mu opioid receptor (MOR) is increased in patients with non-small cell lung cancer (NSCLC), a disease with poor prognosis and limited therapies. In this study, we ...

An investigational, selective mu-opioid receptor inhibitor improved constipation in patients on opioids in randomized phase 2 trial without interfering with analgesic effects.

Wang et al. 2 recently identified the G protein–coupled receptor (GPCR) GPR139 as a molecular brake on the activity of the mu opioid receptor (also a GPCR). The two receptors are represented as ...

The "MU" in MU-MAN plays on Relistor's mechanism of action, which works as a mu-opioid receptor antagonist. In the 60-second ad, MU-MAN’s obstinate mood changes and relief is felt once the ...

Opioids lock to a receptor in the brain that controls pain relief, pleasure and need. A new compound may offer relief without as much risk of addiction or overdose. But it's only been tested in mice.